1sy6
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(New page: 200px<br /> <applet load="1sy6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sy6, resolution 2.1Å" /> '''Crystal Structure of...)
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Revision as of 17:11, 12 November 2007
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Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment
Overview
The CD3 epsilon gamma heterodimer is essential for expression and function, of the T cell receptor. The crystal structure of the human CD3 epsilon, gamma heterodimer is described to 2.1-A resolution complexed with OKT3, a, therapeutic mAb that not only activates and tolerizes mature T cells but, also induces regulatory T cells. The mode of CD3 epsilon gamma, dimerization provides a general structural basis for CD3 assembly and maps, candidate T cell antigen receptor docking sites, including a duplicated, linear region rich in acidic residues that is unique to human CD3 epsilon., OKT3 binds to an atypically small area of CD3 epsilon and has a low, affinity for the isolated CD3 epsilon gamma heterodimer. The structure of, the OKT3/CD3 epsilon gamma complex has implications for T cell signaling, and therapeutic design.
About this Structure
1SY6 is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3., Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J, Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729
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