1qqf
From Proteopedia
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'''N-TERMINALLY TRUNCATED C3D,G FRAGMENT OF THE COMPLEMENT SYSTEM''' | '''N-TERMINALLY TRUNCATED C3D,G FRAGMENT OF THE COMPLEMENT SYSTEM''' | ||
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[[Category: Stoppini, M.]] | [[Category: Stoppini, M.]] | ||
[[Category: Zanotti, G.]] | [[Category: Zanotti, G.]] | ||
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| - | [[Category: | + | [[Category: Complement]] |
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Revision as of 03:35, 3 May 2008
N-TERMINALLY TRUNCATED C3D,G FRAGMENT OF THE COMPLEMENT SYSTEM
Overview
Complement component C3 plays a key role in the complement-mediated immune defence, and occupies a central position within the complement cascade system. One of its degradation products, C3dg, was purified from rat serum and crystallised in two different crystal forms as N-terminally truncated fragment. Despite the truncation and the lack of a significant portion of the N-terminus as compared to C3d, the structure of the fragment is highly similar to that of recombinant human C3d (Nagar et al., Science 280 (1998) 1277-1281). Structural details of the reactive site have been obtained, suggesting a possible mode of thioester bond formation between Cys-1010 and Gln-1013 and thioester bond cleavage in the transacylation reaction involving His-1126. The truncation at the N-terminus of C3d leads to the exposure of a surface of the molecule that favours dimerisation, so that in both crystal forms, the fragment is present as a dimer, with monomers related by a two-fold axis.
About this Structure
1QQF is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure at 1.44 A resolution of an N-terminally truncated form of the rat serum complement C3d fragment., Zanotti G, Bassetto A, Battistutta R, Folli C, Arcidiaco P, Stoppini M, Berni R, Biochim Biophys Acta. 2000 May 23;1478(2):232-8. PMID:10825534 Page seeded by OCA on Sat May 3 06:35:12 2008
