8k8a

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Current revision (12:06, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8k8a is ON HOLD until Paper Publication
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==Crystal structure of NFIL3 in complex with TTACGTAA DNA==
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<StructureSection load='8k8a' size='340' side='right'caption='[[8k8a]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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Authors: Min, J.R., Chen, S.Z., Liu, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8k8a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K8A FirstGlance]. <br>
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Description: Crystal structure of NFIL3 in complex with TTACGTAA DNA
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k8a OCA], [https://pdbe.org/8k8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k8a RCSB], [https://www.ebi.ac.uk/pdbsum/8k8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k8a ProSAT]</span></td></tr>
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[[Category: Min, J.R]]
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</table>
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[[Category: Chen, S.Z]]
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== Function ==
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[[Category: Liu, K]]
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[https://www.uniprot.org/uniprot/NFIL3_HUMAN NFIL3_HUMAN] Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity).[UniProtKB:O08750]<ref>PMID:1620116</ref> <ref>PMID:7565758</ref> <ref>PMID:8836190</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Chen SZ]]
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[[Category: Liu K]]
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[[Category: Min JR]]

Current revision

Crystal structure of NFIL3 in complex with TTACGTAA DNA

PDB ID 8k8a

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OCA

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