8p64
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of PD-L1 with low molecular weight inhibitor== | |
| - | + | <StructureSection load='8p64' size='340' side='right'caption='[[8p64]], [[Resolution|resolution]] 3.31Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8p64]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P64 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.312Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X1Q:~{N}-[[1-[(~{E})-2-(2-methyl-3-phenyl-phenyl)ethenyl]-1,2,3,4-tetrazol-5-yl]methyl]ethanamine'>X1Q</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p64 OCA], [https://pdbe.org/8p64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p64 RCSB], [https://www.ebi.ac.uk/pdbsum/8p64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p64 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Magiera-Mularz | + | <references/> |
| - | [[Category: Musielak | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Van | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Butera R]] | ||
| + | [[Category: Domling A]] | ||
| + | [[Category: Draijer R]] | ||
| + | [[Category: Land L]] | ||
| + | [[Category: Magiera-Mularz K]] | ||
| + | [[Category: Musielak B]] | ||
| + | [[Category: Plewka J]] | ||
| + | [[Category: Surmiak E]] | ||
| + | [[Category: Van der Straat R]] | ||
Revision as of 12:06, 6 March 2024
Co-crystal structure of PD-L1 with low molecular weight inhibitor
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