8pok

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'''Unreleased structure'''
 
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The entry 8pok is ON HOLD until 2025-07-05
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==Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid environment==
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<StructureSection load='8pok' size='340' side='right'caption='[[8pok]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8pok]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8POK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8POK FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HSM:HISTAMINE'>HSM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pok OCA], [https://pdbe.org/8pok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pok RCSB], [https://www.ebi.ac.uk/pdbsum/8pok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pok ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HRH2_HUMAN HRH2_HUMAN] The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Bernhard F]]
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[[Category: Doetsch V]]
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[[Category: Hilger D]]
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[[Category: Januliene D]]
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[[Category: Koeck Z]]
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[[Category: Kolb P]]
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[[Category: Moeller A]]
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[[Category: Parey K]]
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[[Category: Persechino M]]
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[[Category: Pockes S]]
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[[Category: Schihada H]]
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[[Category: Schnelle K]]
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[[Category: Umbach S]]

Revision as of 12:07, 6 March 2024

Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid environment

PDB ID 8pok

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OCA

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