8pol

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'''Unreleased structure'''
 
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The entry 8pol is ON HOLD until Paper Publication
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==Crystal structure of Plasmodium falciparum Sub1 protease==
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<StructureSection load='8pol' size='340' side='right'caption='[[8pol]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
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Authors: Martinez, M., Bouillon, A., Haouz, A., Barale, J.C., Alzari, P.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8pol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8POL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8POL FirstGlance]. <br>
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Description: Crystal structure of Plasmodium falciparum Sub1 protease
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.09&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Bouillon, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pol OCA], [https://pdbe.org/8pol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pol RCSB], [https://www.ebi.ac.uk/pdbsum/8pol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pol ProSAT]</span></td></tr>
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[[Category: Martinez, M]]
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</table>
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[[Category: Barale, J.C]]
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== Function ==
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[[Category: Alzari, P.M]]
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[https://www.uniprot.org/uniprot/SUB1_PLAF7 SUB1_PLAF7] Serine protease which plays an essential role in merozoite invasion of and egress from host erythrocytes by processing and activating various merozoite surface and parasitophorous vacuole proteins (PubMed:18083098, PubMed:19214190, PubMed:21220481, PubMed:29459732). Mediates the proteolytic maturation of serine proteases SERA4, SERA5 and SERA6 just prior to merozoite egress (PubMed:18083098, PubMed:19214190, PubMed:29459732). Prior to merozoite egress, cleaves merozoite surface proteins MSP1, MSP6 and MSP7, which form the MSP1/6/7 complex, and thereby may prime the parasite cell surface for invasion of fresh erythrocytes (PubMed:19214190, PubMed:29459732). Prior to merozoite egress, cleaves MSRP2 converting it to MSRP2 p25 form, and RAP1 converting it to RAP1 p67 form (PubMed:21220481).<ref>PMID:18083098</ref> <ref>PMID:19214190</ref> <ref>PMID:21220481</ref> <ref>PMID:29459732</ref>
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[[Category: Haouz, A]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum]]
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[[Category: Alzari PM]]
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[[Category: Barale JC]]
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[[Category: Bouillon A]]
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[[Category: Haouz A]]
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[[Category: Martinez M]]

Revision as of 12:07, 6 March 2024

Crystal structure of Plasmodium falciparum Sub1 protease

PDB ID 8pol

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