8q66
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the C. elegans MUT-7 MUT-8 CTD complex== | |
| - | + | <StructureSection load='8q66' size='340' side='right'caption='[[8q66]], [[Resolution|resolution]] 2.03Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8q66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q66 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q66 OCA], [https://pdbe.org/8q66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q66 RCSB], [https://www.ebi.ac.uk/pdbsum/8q66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q66 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MUT7_CAEEL MUT7_CAEEL] Represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. Also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers.<ref>PMID:10535732</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caenorhabditis elegans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Busetto V]] | ||
| + | [[Category: Falk S]] | ||
Revision as of 12:07, 6 March 2024
Crystal Structure of the C. elegans MUT-7 MUT-8 CTD complex
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