8rdk

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m (Protected "8rdk" [edit=sysop:move=sysop])
Current revision (12:08, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8rdk is ON HOLD
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==Crystal structure of human Haspin (GSG2) kinase bound to MD420==
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<StructureSection load='8rdk' size='340' side='right'caption='[[8rdk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Kraemer, A., Defois, M., Giraud, F., Moreau, P., Anizon, F., Knapp, S., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8rdk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RDK FirstGlance]. <br>
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Description: Crystal structure of human Haspin (GSG2) kinase bound to MD420
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=YQT:3-pyridin-4-yl-1~{H}-pyrrolo[3,2-g]isoquinoline'>YQT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Moreau, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rdk OCA], [https://pdbe.org/8rdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rdk RCSB], [https://www.ebi.ac.uk/pdbsum/8rdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rdk ProSAT]</span></td></tr>
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[[Category: Knapp, S]]
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</table>
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[[Category: Giraud, F]]
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== Function ==
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[[Category: Anizon, F]]
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[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
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[[Category: Defois, M]]
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== References ==
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[[Category: Structural Genomics Consortium (Sgc)]]
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<references/>
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[[Category: Kraemer, A]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Anizon F]]
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[[Category: Defois M]]
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[[Category: Giraud F]]
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[[Category: Knapp S]]
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[[Category: Kraemer A]]
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[[Category: Moreau P]]

Current revision

Crystal structure of human Haspin (GSG2) kinase bound to MD420

PDB ID 8rdk

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