8tl8

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Current revision (12:10, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8tl8 is ON HOLD until Paper Publication
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==Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant in complex with bile acid==
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<StructureSection load='8tl8' size='340' side='right'caption='[[8tl8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors: Prasad, B.V.V., Zhao, B., Hu, L., Neetu, N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8tl8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthoreovirus Orthoreovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TL8 FirstGlance]. <br>
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Description: Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant in complex with bile acid
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCH:GLYCOCHOLIC+ACID'>GCH</scene></td></tr>
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[[Category: Hu, L]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tl8 OCA], [https://pdbe.org/8tl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tl8 RCSB], [https://www.ebi.ac.uk/pdbsum/8tl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tl8 ProSAT]</span></td></tr>
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[[Category: Zhao, B]]
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</table>
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[[Category: Prasad, B.V.V]]
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== Function ==
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[[Category: Neetu, N]]
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[https://www.uniprot.org/uniprot/SIGNS_REOVD SIGNS_REOVD] Protein that binds to ssRNA and participates with protein mu-NS in forming the matrix of viral factories, which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place (PubMed:11152519). Plays a role in the inhibition of the integrated stress response (ISR) to escape from host cell translational shutoff (PubMed:28794026). Participates in the disruption of stress granules (SG) through its association with host G3BP1 and mu-NS (PubMed:28794026).<ref>PMID:11152519</ref> <ref>PMID:28794026</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Orthoreovirus]]
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[[Category: Hu L]]
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[[Category: Neetu N]]
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[[Category: Prasad BVV]]
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[[Category: Zhao B]]

Current revision

Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant in complex with bile acid

PDB ID 8tl8

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OCA

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