1xpn

<StructureSection load='1xpn' size='340' side='right'caption='[[1xpn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1xpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XPN FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA1324 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpn OCA], [http://pdbe.org/1xpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xpn RCSB], [http://www.ebi.ac.uk/pdbsum/1xpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpn ProSAT], [http://www.topsan.org/Proteins/NESGC/1xpn TOPSAN]</span></td></tr>

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== Publication Abstract from PubMed ==

Pseudomonas aeruginosa is the prototypical biofilm-forming gram-negative opportunistic human pathogen. P. aeruginosa is causatively associated with nosocomial infections and with cystic fibrosis. Antibiotic resistance in some strains adds to the inherent difficulties that result from biofilm formation when treating P. aeruginosa infections. Transcriptional profiling studies suggest widespread changes in the proteome during quorum sensing and biofilm development. Many of the proteins found to be upregulated during these processes are poorly characterized from a functional standpoint. Here, we report the solution NMR structure of PA1324, a protein of unknown function identified in these studies, and provide a putative biological functional assignment based on the observed prealbumin-like fold and FAST-NMR ligand screening studies. PA1324 is postulated to be involved in the binding and transport of sugars or polysaccharides associated with the peptidoglycan matrix during biofilm formation.

Structure and function of Pseudomonas aeruginosa protein PA1324 (21-170).,Mercier KA, Cort JR, Kennedy MA, Lockert EE, Ni S, Shortridge MD, Powers R Protein Sci. 2009 Mar;18(3):606-18. PMID:19241370<ref>PMID:19241370</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1xpn" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Pseae]]

[[Category: Cort, J R]]

[[Category: Kennedy, M A]]

[[Category: Lockert, E E]]

[[Category: Montelione, G T]]

[[Category: Structural genomic]]

[[Category: Ni, S]]

[[Category: Unknown function]]