1qrz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1qrz.gif|left|200px]]
[[Image:1qrz.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1qrz |SIZE=350|CAPTION= <scene name='initialview01'>1qrz</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_1qrz", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=ACA:Active+Site+For+Chain+A'>ACA</scene>, <scene name='pdbsite=ACB:Active+Site+For+Chain+B'>ACB</scene>, <scene name='pdbsite=ACC:Active+Site+For+Chain+C'>ACC</scene> and <scene name='pdbsite=ACD:Active+Site+For+Chain+D'>ACD</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1qrz| PDB=1qrz | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qrz OCA], [http://www.ebi.ac.uk/pdbsum/1qrz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qrz RCSB]</span>
+
-
}}
+
'''CATALYTIC DOMAIN OF PLASMINOGEN'''
'''CATALYTIC DOMAIN OF PLASMINOGEN'''
Line 30: Line 27:
[[Category: Santos, T de los.]]
[[Category: Santos, T de los.]]
[[Category: Wang, J.]]
[[Category: Wang, J.]]
-
[[Category: chymotrypsin family]]
+
[[Category: Chymotrypsin family]]
-
[[Category: microplasminogen]]
+
[[Category: Microplasminogen]]
-
[[Category: serine protease]]
+
[[Category: Serine protease]]
-
[[Category: zymogen]]
+
[[Category: Zymogen]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:38:10 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:18:09 2008''
+

Revision as of 03:38, 3 May 2008

Image:1qrz.gif

Template:STRUCTURE 1qrz

CATALYTIC DOMAIN OF PLASMINOGEN


Overview

We have solved the X-ray crystal structure of the proenzyme form of the catalytic domain of plasminogen, with the nonessential mutations M585Q, V673M, and M788L, to 2.0 A resolution. The structure presents an inactive protease characterized by Asp740 (chymotrypsinogen 194) hydrogen bonded to His586 (chymotrypsinogen 40), preventing proper formation of the oxyanion hole and S1 specificity pocket. In addition, the catalytic triad residues are misplaced relative to the active conformation adopted by serine proteases in the chymotrypsin family. Finally, a unique form of zymogen inactivation is observed, characterized by a "foot-in-mouth" mechanism in which Trp761 (chymotrypsinogen 215) is folded into the S1 specificity pocket preventing substrate binding.

About this Structure

1QRZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the proenzyme domain of plasminogen., Peisach E, Wang J, de los Santos T, Reich E, Ringe D, Biochemistry. 1999 Aug 24;38(34):11180-8. PMID:10460175 Page seeded by OCA on Sat May 3 06:38:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qrz"
Personal tools