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1qsf
From Proteopedia
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[[Image:1qsf.gif|left|200px]] | [[Image:1qsf.gif|left|200px]] | ||
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'''STRUCTURE OF A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE Y8A''' | '''STRUCTURE OF A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE Y8A''' | ||
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[[Category: Garboczi, D. N.]] | [[Category: Garboczi, D. N.]] | ||
[[Category: Wiley, D. C.]] | [[Category: Wiley, D. C.]] | ||
| - | [[Category: | + | [[Category: Hla-a2]] |
| - | [[Category: | + | [[Category: Human t cell receptor]] |
| - | [[Category: | + | [[Category: Tcr/peptide/mhc complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:39:04 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:39, 3 May 2008
STRUCTURE OF A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE Y8A
Overview
The interactions of three singly substituted peptide variants of the HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T cell assays, kinetic and thermodynamic measurements, and X-ray crystallography. The three peptide/MHC ligands include weak agonists and antagonists with different affinities for TCR. The three-dimensional structures of the three A6-TCR/peptide/HLA-A2 complexes are remarkably similar to each other and to the wild-type agonist complex, with minor adjustments at the interface to accommodate the peptide substitutions (P6A, V7R, and Y8A). The lack of correlation between structural changes and the type of T cell signals induced provides direct evidence that different signals are not generated by different ligand-induced conformational changes in the alphabeta TCR.
About this Structure
1QSF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical., Ding YH, Baker BM, Garboczi DN, Biddison WE, Wiley DC, Immunity. 1999 Jul;11(1):45-56. PMID:10435578 Page seeded by OCA on Sat May 3 06:39:04 2008
