5tss

<table><tr><td colspan='2'>[[5tss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TSS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TSS FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tss OCA], [http://pdbe.org/5tss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tss RCSB], [http://www.ebi.ac.uk/pdbsum/5tss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tss ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU]] Responsible for the symptoms of toxic shock syndrome.

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The structure of toxic shock syndrome toxin-1 (TSST-1), the causative agent in toxic shock syndrome, has been determined in three crystal forms. The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between two symmetry-related molecules. Although not required for biological activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very low concentrations. In addition, the structure of the tetramutant TSST-1H [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify endotoxin shock, has been determined and refined in a fourth crystal form (R-factor = 0.173 to 1.9 A resolution).

Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity.,Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH Protein Sci. 1997 Jun;6(6):1220-7. PMID:9194182<ref>PMID:9194182</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 5tss" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Cook, W J]]

[[Category: Dinges, M M]]

[[Category: Earhart, C A]]

[[Category: Mitchell, D T]]

[[Category: Ohlendorf, D H]]

[[Category: Prasad, G S]]

[[Category: Radhakrishnan, R]]

[[Category: Schlivert, P M]]

[[Category: Toxin]]