5vc9

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Current revision (14:32, 6 March 2024) (edit) (undo)
 
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==Zinc finger of human CXXC4 in complex with CpG DNA==
==Zinc finger of human CXXC4 in complex with CpG DNA==
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<StructureSection load='5vc9' size='340' side='right' caption='[[5vc9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5vc9' size='340' side='right'caption='[[5vc9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vc9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VC9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vc9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VC9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CXXC4, IDAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vc9 OCA], [http://pdbe.org/5vc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vc9 RCSB], [http://www.ebi.ac.uk/pdbsum/5vc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vc9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vc9 OCA], [https://pdbe.org/5vc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vc9 RCSB], [https://www.ebi.ac.uk/pdbsum/5vc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vc9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CXXC4_HUMAN CXXC4_HUMAN]] Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.
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[https://www.uniprot.org/uniprot/CXXC4_HUMAN CXXC4_HUMAN] Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The CXXC domain, first identified as the reader of unmodified CpG dinucleotide, plays important roles in epigenetic regulation by targeting various activities to CpG islands. Here we systematically measured and compared the DNA-binding selectivities of all known human CXXC domains by different binding assays, and complemented the existing function-based classification of human CXXC domains with a classification based on their DNA selectivities. Through a series of crystal structures of CXXC domains with DNA ligands, we unravel the molecular mechanisms of how these CXXC domains, including single CXXC domains and tandem CXXC-PHD domains, recognize distinct DNA ligands, which further supports our classification of human CXXC domains and also provides insights into selective recruitment of chromatin modifiers to their respective targets via CXXC domains recognizing different genomic DNA sequences. Our study facilitates the understanding of the relationship between the DNA-binding specificities of the CXXC proteins and their biological functions.
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DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.,Xu C, Liu K, Lei M, Yang A, Li Y, Hughes TR, Min J Structure. 2017 Dec 16. pii: S0969-2126(17)30396-9. doi:, 10.1016/j.str.2017.11.022. PMID:29276034<ref>PMID:29276034</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5vc9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Synthetic construct]]
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[[Category: Edwards, A M]]
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[[Category: Arrowsmith CH]]
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[[Category: Liu, K]]
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[[Category: Bountra C]]
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[[Category: Min, J]]
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[[Category: Edwards AM]]
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[[Category: Structural genomic]]
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[[Category: Liu K]]
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[[Category: Tempel, W]]
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[[Category: Min J]]
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[[Category: Walker, J R]]
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[[Category: Tempel W]]
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[[Category: Xu, C]]
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[[Category: Walker JR]]
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[[Category: Cxxc]]
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[[Category: Xu C]]
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[[Category: Dna]]
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[[Category: Dna binding protein]]
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[[Category: Sgc]]
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Current revision

Zinc finger of human CXXC4 in complex with CpG DNA

PDB ID 5vc9

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