6v8i

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Current revision (14:36, 6 March 2024) (edit) (undo)
 
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<SX load='6v8i' size='340' side='right' viewer='molstar' caption='[[6v8i]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<SX load='6v8i' size='340' side='right' viewer='molstar' caption='[[6v8i]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6v8i]] is a 72 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V8I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v8i]] is a 72 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_virus_80alpha Staphylococcus virus 80alpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V8I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8i OCA], [http://pdbe.org/6v8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v8i RCSB], [http://www.ebi.ac.uk/pdbsum/6v8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8i ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8i OCA], [https://pdbe.org/6v8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v8i RCSB], [https://www.ebi.ac.uk/pdbsum/6v8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8i ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A4ZFC4_9CAUD A4ZFC4_9CAUD]
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Staphylococcus aureus is a common cause of infections in humans. The emergence of virulent, antibiotic-resistant strains of S. aureus is a significant public health concern. Most virulence and resistance factors in S. aureus are encoded by mobile genetic elements, and transduction by bacteriophages represents the main mechanism for horizontal gene transfer. The baseplate is a specialized structure at the tip of bacteriophage tails that plays key roles in host recognition, cell wall penetration, and DNA ejection. We have used high-resolution cryo-electron microscopy to determine the structure of the S. aureus bacteriophage 80alpha baseplate at 3.75 A resolution, allowing atomic models to be built for most of the major tail and baseplate proteins, including two tail fibers, the receptor binding protein, and part of the tape measure protein. Our structure provides a structural basis for understanding host recognition, cell wall penetration and DNA ejection in viruses infecting Gram-positive bacteria. Comparison to other phages demonstrates the modular design of baseplate proteins, and the adaptations to the host that take place during the evolution of staphylococci and other pathogens.
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Structure of the host cell recognition and penetration machinery of a Staphylococcus aureus bacteriophage.,Kizziah JL, Manning KA, Dearborn AD, Dokland T PLoS Pathog. 2020 Feb 18;16(2):e1008314. doi: 10.1371/journal.ppat.1008314., eCollection 2020 Feb. PMID:32069326<ref>PMID:32069326</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6v8i" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dokland, T]]
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[[Category: Staphylococcus virus 80alpha]]
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[[Category: Kizziah, J L]]
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[[Category: Dokland T]]
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[[Category: Phage tail]]
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[[Category: Kizziah JL]]
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[[Category: Tail tip]]
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[[Category: Tape measure protein]]
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[[Category: Viral protein]]
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Current revision

Composite atomic model of the Staphylococcus aureus phage 80alpha baseplate

6v8i, resolution 3.70Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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