6vy1

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<StructureSection load='6vy1' size='340' side='right'caption='[[6vy1]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
<StructureSection load='6vy1' size='340' side='right'caption='[[6vy1]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6vy1]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VY1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VY1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6vy1]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VY1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pfdA2, MJ0648 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vy1 OCA], [http://pdbe.org/6vy1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vy1 RCSB], [http://www.ebi.ac.uk/pdbsum/6vy1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vy1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vy1 OCA], [https://pdbe.org/6vy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vy1 RCSB], [https://www.ebi.ac.uk/pdbsum/6vy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vy1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PFDA2_METJA PFDA2_METJA]] Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
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[https://www.uniprot.org/uniprot/PFDA2_METJA PFDA2_METJA] Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The transfer of electrons through protein complexes is central to cellular respiration. Exploiting proteins for charge transfer in a controllable fashion has the potential to revolutionize the integration of biological systems and electronic devices. Here we characterize the structure of an ultrastable protein filament and engineer the filament subunits to create electronically conductive nanowires under aqueous conditions. Cryoelectron microscopy was used to resolve the helical structure of gamma-prefoldin, a filamentous protein from a hyperthermophilic archaeon. Conjugation of tetra-heme c3-type cytochromes along the longitudinal axis of the filament created nanowires capable of long-range electron transfer. Electrochemical transport measurements indicated networks of the nanowires capable of conducting current between electrodes at the redox potential of the cytochromes. Functionalization of these highly engineerable nanowires with other molecules, such as redox enzymes, may be useful for bioelectronic applications.
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Structural Determination of a Filamentous Chaperone to Fabricate Electronically Conductive Metalloprotein Nanowires.,Chen YX, Ing NL, Wang F, Xu D, Sloan NB, Lam NT, Winter DL, Egelman EH, Hochbaum AI, Clark DS, Glover DJ ACS Nano. 2020 May 7. doi: 10.1021/acsnano.9b09405. PMID:32347705<ref>PMID:32347705</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6vy1" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Metja]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: Chen, Y X]]
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[[Category: Chen YX]]
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[[Category: Clark, D S]]
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[[Category: Clark DS]]
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[[Category: Egelman, E H]]
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[[Category: Egelman EH]]
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[[Category: Glover, D J]]
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[[Category: Glover DJ]]
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[[Category: Hochbaum, A I]]
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[[Category: Hochbaum AI]]
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[[Category: Ing, N L]]
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[[Category: Ing NL]]
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[[Category: Wang, F]]
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[[Category: Wang F]]
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[[Category: Helical symmetry]]
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[[Category: Nanowire]]
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[[Category: Prefoldin]]
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[[Category: Protein fibril]]
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Revision as of 14:40, 6 March 2024

Cryo-EM structure of filamentous PFD from Methanocaldococcus jannaschii

PDB ID 6vy1

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