6w7n

==30S-Inactive-low-Mg2+ Class A==

<StructureSection load='6w7n' size='340' side='right'caption='[[6w7n]], [[Resolution|resolution]] 3.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[6w7n]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W7N FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w7n OCA], [https://pdbe.org/6w7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w7n RCSB], [https://www.ebi.ac.uk/pdbsum/6w7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w7n ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/RS12_ECOLI RS12_ECOLI] With S4 and S5 plays an important role in translational accuracy.[HAMAP-Rule:MF_00403_B] Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).[HAMAP-Rule:MF_00403_B] Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit.[HAMAP-Rule:MF_00403_B]

==See Also==

*[[Ribosome 3D structures|Ribosome 3D structures]]

[[Category: Escherichia coli K-12]]

[[Category: Basu B]]

[[Category: Gomez-Blanco J]]

[[Category: Vargas J]]