This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6wlg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:45, 6 March 2024) (edit) (undo)
 
Line 1: Line 1:
==Ints3 C-terminal Domain==
==Ints3 C-terminal Domain==
-
<StructureSection load='6wlg' size='340' side='right'caption='[[6wlg]]' scene=''>
+
<StructureSection load='6wlg' size='340' side='right'caption='[[6wlg]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WLG FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6wlg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WLG FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wlg OCA], [https://pdbe.org/6wlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wlg RCSB], [https://www.ebi.ac.uk/pdbsum/6wlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wlg ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.111&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wlg OCA], [https://pdbe.org/6wlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wlg RCSB], [https://www.ebi.ac.uk/pdbsum/6wlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wlg ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/INT3_HUMAN INT3_HUMAN] Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref>
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Banerjee S]]
[[Category: Banerjee S]]

Current revision

Ints3 C-terminal Domain

PDB ID 6wlg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6wlg"
Personal tools