6wqz
From Proteopedia
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==Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery== | ==Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery== | ||
| - | <StructureSection load='6wqz' size='340' side='right'caption='[[6wqz]]' scene=''> | + | <StructureSection load='6wqz' size='340' side='right'caption='[[6wqz]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQZ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6wqz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WQZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wqz OCA], [https://pdbe.org/6wqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wqz RCSB], [https://www.ebi.ac.uk/pdbsum/6wqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wqz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATG9A_HUMAN ATG9A_HUMAN] Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.<ref>PMID:16940348</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Banerjee A]] | [[Category: Banerjee A]] | ||
Revision as of 14:46, 6 March 2024
Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery
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Categories: Homo sapiens | Large Structures | Banerjee A | Bonifacino JS | Christenson ET | Faraldo-Gomez JD | Guardia CM | Jiang J | Lian T | Lowry AJ | Rana MS | Tan X | Zhou W
