6xjv

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Current revision (14:50, 6 March 2024) (edit) (undo)
 
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====
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==MCU holocomplex in High-calcium state==
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<StructureSection load='6xjv' size='340' side='right'caption='[[6xjv]]' scene=''>
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<StructureSection load='6xjv' size='340' side='right'caption='[[6xjv]], [[Resolution|resolution]] 4.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6xjv]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XJV FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjv OCA], [http://pdbe.org/6xjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xjv RCSB], [http://www.ebi.ac.uk/pdbsum/6xjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjv ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.17&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjv OCA], [https://pdbe.org/6xjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xjv RCSB], [https://www.ebi.ac.uk/pdbsum/6xjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjv ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCU_HUMAN MCU_HUMAN] Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.<ref>PMID:21685886</ref> <ref>PMID:21685888</ref> <ref>PMID:22822213</ref> <ref>PMID:22829870</ref> <ref>PMID:22904319</ref> <ref>PMID:23101630</ref> <ref>PMID:23178883</ref> <ref>PMID:24332854</ref> <ref>PMID:24560927</ref>
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==See Also==
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*[[Calcium uptake protein 3D structures|Calcium uptake protein 3D structures]]
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*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Jiang Y]]
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[[Category: Wang Y]]

Current revision

MCU holocomplex in High-calcium state

PDB ID 6xjv

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