7k6p

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m (Protected "7k6p" [edit=sysop:move=sysop])
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====
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==Active state Dot1 bound to the unacetylated H4 nucleosome==
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<StructureSection load='7k6p' size='340' side='right'caption='[[7k6p]]' scene=''>
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<StructureSection load='7k6p' size='340' side='right'caption='[[7k6p]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7k6p]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K6P FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k6p OCA], [https://pdbe.org/7k6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k6p RCSB], [https://www.ebi.ac.uk/pdbsum/7k6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k6p ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k6p OCA], [https://pdbe.org/7k6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k6p RCSB], [https://www.ebi.ac.uk/pdbsum/7k6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k6p ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1_YEAST DOT1_YEAST] Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro).<ref>PMID:9755194</ref> <ref>PMID:11029058</ref> <ref>PMID:12097318</ref> <ref>PMID:12152067</ref> <ref>PMID:12574507</ref> <ref>PMID:15632126</ref> <ref>PMID:16166626</ref> <ref>PMID:15292170</ref>
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Synthetic construct]]
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[[Category: Xenopus laevis]]
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[[Category: Armache J-P]]
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[[Category: Armache K-J]]
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[[Category: Boeke JD]]
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[[Category: De Ioannes PE]]
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[[Category: Lee R]]
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[[Category: Miao W]]
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[[Category: Truong DM]]
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[[Category: Valencia-Sanchez MI]]

Current revision

Active state Dot1 bound to the unacetylated H4 nucleosome

PDB ID 7k6p

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