7kaq

==Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore mutant, class with Sec62, conformation 2 (C2)==

<StructureSection load='7kaq' size='340' side='right'caption='[[7kaq]], [[Resolution|resolution]] 4.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[7kaq]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_BY4741 Saccharomyces cerevisiae BY4741]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KAQ FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kaq OCA], [https://pdbe.org/7kaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kaq RCSB], [https://www.ebi.ac.uk/pdbsum/7kaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kaq ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/SEC72_YEAST SEC72_YEAST] Acts as non-essential component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC72 may be involved in signal peptide recognition for a defined subset of leader peptides, or may increase the efficiency of unusual or "difficult" secretory precursors to the translocation pore, it may be that this protein binds charged leader peptides to the membrane until they engage the translocation apparatus.

[[Category: Saccharomyces cerevisiae BY4741]]

[[Category: Park E]]