7kco
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==ROR gamma in complex with SCR2 and compound 3== |
| - | <StructureSection load='7kco' size='340' side='right'caption='[[7kco]]' scene=''> | + | <StructureSection load='7kco' size='340' side='right'caption='[[7kco]], [[Resolution|resolution]] 1.86Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7kco]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KCO FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kco OCA], [https://pdbe.org/7kco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kco RCSB], [https://www.ebi.ac.uk/pdbsum/7kco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kco ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WB7:1-[(2-chlorophenyl)methyl]-N-{[4-(methylsulfonyl)phenyl]methyl}-4,5-dihydrospiro[piperidine-4,7-thieno[2,3-c]pyran]-2-carboxamide'>WB7</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kco OCA], [https://pdbe.org/7kco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kco RCSB], [https://www.ebi.ac.uk/pdbsum/7kco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kco ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Clawson DK]] |
| + | [[Category: Durbin JD]] | ||
| + | [[Category: Guo SY]] | ||
| + | [[Category: Stout SL]] | ||
Current revision
ROR gamma in complex with SCR2 and compound 3
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