7kxr

==Protective antigen pore translocating lethal factor N-terminal domain==

<StructureSection load='7kxr' size='340' side='right'caption='[[7kxr]], [[Resolution|resolution]] 3.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[7kxr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KXR FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kxr OCA], [https://pdbe.org/7kxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kxr RCSB], [https://www.ebi.ac.uk/pdbsum/7kxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kxr ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.

==See Also==

*[[Anthrax lethal factor 3D structures|Anthrax lethal factor 3D structures]]

[[Category: Bacillus anthracis]]

[[Category: Freudenthal BD]]

[[Category: Machen AJ]]