7kyq

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Current revision (14:58, 6 March 2024) (edit) (undo)
 
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==Crystal structure of human BCCIP beta (Native1)==
==Crystal structure of human BCCIP beta (Native1)==
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<StructureSection load='7kyq' size='340' side='right'caption='[[7kyq]]' scene=''>
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<StructureSection load='7kyq' size='340' side='right'caption='[[7kyq]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KYQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7kyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KYQ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyq OCA], [https://pdbe.org/7kyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyq RCSB], [https://www.ebi.ac.uk/pdbsum/7kyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyq ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.06&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyq OCA], [https://pdbe.org/7kyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyq RCSB], [https://www.ebi.ac.uk/pdbsum/7kyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyq ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BCCIP_HUMAN BCCIP_HUMAN] During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).<ref>PMID:10878006</ref> <ref>PMID:14726710</ref> <ref>PMID:15539944</ref> <ref>PMID:15713648</ref> <ref>PMID:17947333</ref> <ref>PMID:28394342</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Choi WS]]
[[Category: Choi WS]]

Current revision

Crystal structure of human BCCIP beta (Native1)

PDB ID 7kyq

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