7l9p

==Structure of human SHLD2-SHLD3-REV7-TRIP13(E253Q) complex==

<StructureSection load='7l9p' size='340' side='right'caption='[[7l9p]], [[Resolution|resolution]] 3.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[7l9p]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L9P FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l9p OCA], [https://pdbe.org/7l9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l9p RCSB], [https://www.ebi.ac.uk/pdbsum/7l9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l9p ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/PCH2_HUMAN PCH2_HUMAN] Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).

[[Category: Homo sapiens]]

[[Category: Patel DJ]]

[[Category: Xie W]]