1qu9

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[[Image:1qu9.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1qu9| PDB=1qu9 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu9 OCA], [http://www.ebi.ac.uk/pdbsum/1qu9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qu9 RCSB]</span>
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'''1.2 A CRYSTAL STRUCTURE OF YJGF GENE PRODUCT FROM E. COLI'''
'''1.2 A CRYSTAL STRUCTURE OF YJGF GENE PRODUCT FROM E. COLI'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Volz, K.]]
[[Category: Volz, K.]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:42:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:19:06 2008''
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Revision as of 03:42, 3 May 2008

Image:1qu9.gif

Template:STRUCTURE 1qu9

1.2 A CRYSTAL STRUCTURE OF YJGF GENE PRODUCT FROM E. COLI


Overview

The YER057c/YIL051c/YjgF protein family is a set of 24 full-length homologs, each approximately 130 residues in length, and each with no known function or relationship to proteins of known structure. To determine the function of this family, the structure of one member--the YjgF protein from Escherichia coli--was solved and refined at a resolution of 1.2 A. The YjgF molecule is a homotrimer with exact threefold symmetry. Its tertiary and quaternary structures are related to that of Bacillus subtilis chorismate mutase, although their active sites are completely different. The YjgF protein has an active site curiously similar to protein tyrosine phosphatases, including a covalently modified cysteine, but it is unlikely to be functionally related. The lessons learned from this attempt to deduce function from structure may be useful to future projects in structural genomics.

About this Structure

1QU9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A test case for structure-based functional assignment: the 1.2 A crystal structure of the yjgF gene product from Escherichia coli., Volz K, Protein Sci. 1999 Nov;8(11):2428-37. PMID:10595546 Page seeded by OCA on Sat May 3 06:42:40 2008

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