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5tj6

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Current revision (15:41, 6 March 2024) (edit) (undo)
 
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<SX load='5tj6' size='340' side='right' viewer='molstar' caption='[[5tj6]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<SX load='5tj6' size='340' side='right' viewer='molstar' caption='[[5tj6]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tj6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TJ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tj6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TJ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jti|5jti]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tj6 OCA], [http://pdbe.org/5tj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tj6 RCSB], [http://www.ebi.ac.uk/pdbsum/5tj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tj6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tj6 OCA], [https://pdbe.org/5tj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tj6 RCSB], [https://www.ebi.ac.uk/pdbsum/5tj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tj6 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q5QJC5_APLCA Q5QJC5_APLCA]
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The Ca2+-activated K+ channel, Slo1, has an unusually large conductance and contains a voltage sensor and multiple chemical sensors. Dual activation by membrane voltage and Ca2+ renders Slo1 central to processes that couple electrical signalling to Ca2+-mediated events such as muscle contraction and neuronal excitability. Here we present the cryo-electron microscopy structure of a full-length Slo1 channel from Aplysia californica in the presence of Ca2+ and Mg2+ at a resolution of 3.5 A. The channel adopts an open conformation. Its voltage-sensor domain adopts a non-domain-swapped attachment to the pore and contacts the cytoplasmic Ca2+-binding domain from a neighbouring subunit. Unique structural features of the Slo1 voltage sensor suggest that it undergoes different conformational changes than other known voltage sensors. The structure reveals the molecular details of three distinct divalent cation-binding sites identified through electrophysiological studies of mutant Slo1 channels.
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Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel.,Tao X, Hite RK, MacKinnon R Nature. 2017 Jan 5;541(7635):46-51. doi: 10.1038/nature20608. Epub 2016 Dec 14. PMID:27974795<ref>PMID:27974795</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5tj6" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Aplca]]
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[[Category: Aplysia californica]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hite, R K]]
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[[Category: Hite RK]]
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[[Category: MacKinnon, R]]
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[[Category: MacKinnon R]]
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[[Category: Tao, X]]
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[[Category: Tao X]]
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[[Category: Ca2+ bound]]
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[[Category: High conductance]]
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[[Category: Ion channel]]
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[[Category: K+ channel]]
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[[Category: Membrane protein]]
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Current revision

Ca2+ bound aplysia Slo1

5tj6, resolution 3.40Å

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