5tqq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<SX load='5tqq' size='340' side='right' viewer='molstar' caption='[[5tqq]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
<SX load='5tqq' size='340' side='right' viewer='molstar' caption='[[5tqq]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5tqq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TQQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TQQ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5tqq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TQQ FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tr1|5tr1]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.76&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LOC101909378 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tqq OCA], [https://pdbe.org/5tqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tqq RCSB], [https://www.ebi.ac.uk/pdbsum/5tqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tqq ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tqq OCA], [http://pdbe.org/5tqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tqq RCSB], [http://www.ebi.ac.uk/pdbsum/5tqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tqq ProSAT]</span></td></tr>
+
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/E1B792_BOVIN E1B792_BOVIN]
-
CLC proteins transport chloride (Cl-) ions across cellular membranes to regulate muscle excitability, electrolyte movement across epithelia, and acidification of intracellular organelles. Some CLC proteins are channels that conduct Cl- ions passively, whereas others are secondary active transporters that exchange two Cl- ions for one H+. The structural basis underlying these distinctive transport mechanisms is puzzling because CLC channels and transporters are expected to share the same architecture on the basis of sequence homology. Here we determined the structure of a bovine CLC channel (CLC-K) using cryo-electron microscopy. A conserved loop in the Cl- transport pathway shows a structure markedly different from that of CLC transporters. Consequently, the cytosolic constriction for Cl- passage is widened in CLC-K such that the kinetic barrier previously postulated for Cl-/H+ transporter function would be reduced. Thus, reduction of a kinetic barrier in CLC channels enables fast flow of Cl- down its electrochemical gradient.
+
-
 
+
-
Structure of a CLC chloride ion channel by cryo-electron microscopy.,Park E, Campbell EB, MacKinnon R Nature. 2016 Dec 21. doi: 10.1038/nature20812. PMID:28002411<ref>PMID:28002411</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 5tqq" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
*[[Ion channels 3D structures|Ion channels 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-
== References ==
 
-
<references/>
 
__TOC__
__TOC__
</SX>
</SX>
-
[[Category: Bovin]]
+
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Lk3 transgenic mice]]
+
[[Category: Mus musculus]]
-
[[Category: MacKinnon, R]]
+
[[Category: MacKinnon R]]
-
[[Category: Park, E]]
+
[[Category: Park E]]
-
[[Category: Chloride channel]]
+
-
[[Category: Clc]]
+
-
[[Category: Kidney]]
+
-
[[Category: Membrane]]
+
-
[[Category: Transport protein]]
+

Revision as of 15:42, 6 March 2024

Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation

5tqq, resolution 3.76Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5tqq"
Personal tools