Ubiquitin protein ligase 3D structures

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Line 639: Line 639:
*'''Ubiquitin protein ligase UBR'''
*'''Ubiquitin protein ligase UBR'''
-
**[[3ny1]], [[3ny2]] – hUPL 1 UBR-box <br />
+
**[[8d4x]]– hUPL 1 – Cryo EM<br />
 +
**[[3ny1]], [[3ny2]] – hUPL 1 UBR-box 98-168 <br />
**[[3ny3]] – hUPL 1 UBR-box + N-degron<br />
**[[3ny3]] – hUPL 1 UBR-box + N-degron<br />
**[[5tdc]] – hUPL 1 UBR-box + peptide<br />
**[[5tdc]] – hUPL 1 UBR-box + peptide<br />
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**[[5tda]] – hUPL 2 UBR-box + N-degron<br />
**[[5tda]] – hUPL 2 UBR-box + N-degron<br />
**[[5tdd]], [[5tdb]] – hUPL 2 UBR-box + peptide<br />
**[[5tdd]], [[5tdb]] – hUPL 2 UBR-box + peptide<br />
 +
**[[8j9q]], [[8j9r]] – hUPL 4 UBR-box <br />
 +
**[[8bja]], [[8e0q]] – hUPL 5 – Cryo EM <br />
 +
**[[8c06]] – hUPL 5 (mutant) – Cryo EM <br />
 +
**[[8c07]] – hUPL 5 + polyubiquitin-B – Cryo EM <br />
**[[3pt3]] – hUPL 5 C terminal <br />
**[[3pt3]] – hUPL 5 C terminal <br />
**[[5vmd]] – hUPL 6 UBR-box <br />
**[[5vmd]] – hUPL 6 UBR-box <br />
**[[3ntw]] – rUPL 5 MLLE domain + peptide <br />
**[[3ntw]] – rUPL 5 MLLE domain + peptide <br />
-
**[[3nis]], [[3nit]], [[6kgi]] – yUPL 1 UBR-box - yeast <br />
+
**[[3nis]], [[3nit]], [[6kgi]] – yUPL 1 UBR-box <br />
**[[3nih]], [[3nii]], [[3nij]], [[3nik]], [[3nil]], [[3nim]], [[3nin]] – yUPL 1 UBR-box + peptide<br />
**[[3nih]], [[3nii]], [[3nij]], [[3nik]], [[3nil]], [[3nim]], [[3nin]] – yUPL 1 UBR-box + peptide<br />
Line 680: Line 685:
**[[5xpi]], [[4qqd]] – hUPL 1 TUDOR domain + inhibitor<br />
**[[5xpi]], [[4qqd]] – hUPL 1 TUDOR domain + inhibitor<br />
**[[6vyj]], [[7fb7]] – hUPL 1 TTD domain + inhibitor<br />
**[[6vyj]], [[7fb7]] – hUPL 1 TTD domain + inhibitor<br />
 +
**[[5yy9]] – hUPL 1 TTD domain + peptide<br />
**[[6vcs]] – hUPL 1 SRA domain + DNA<br />
**[[6vcs]] – hUPL 1 SRA domain + DNA<br />
**[[4pw5]], [[4pw6]], [[4pw7]] – hUPL 2 SRA domain + DNA<br />
**[[4pw5]], [[4pw6]], [[4pw7]] – hUPL 2 SRA domain + DNA<br />
-
**[[2zo0]], [[2zo1]], [[2zo2]], [[3f8i]], [[3f8j]], [[3fde]] – mUPL 1 SRA domain + DNA<br />
+
**[[2zo0]], [[2zo1]], [[2zo2]], [[3f8i]], [[3f8j]], [[3fde]], [[6m2v]] – mUPL 1 SRA domain + DNA<br />
*'''Ubiquitin protein ligase XIAP or baculoviral IAP repeat containing protein 4''' Domains: BIR1 10-99; BIR2 152-236; BIR3 249-354; UBA 357-449; RING 429-497
*'''Ubiquitin protein ligase XIAP or baculoviral IAP repeat containing protein 4''' Domains: BIR1 10-99; BIR2 152-236; BIR3 249-354; UBA 357-449; RING 429-497
Line 690: Line 696:
**[[4j3y]] – hXIAP BIR2 domain (mutant) <BR />
**[[4j3y]] – hXIAP BIR2 domain (mutant) <BR />
**[[1f9x]] – hXIAP BIR3 domain – NMR <BR />>
**[[1f9x]] – hXIAP BIR3 domain – NMR <BR />>
-
**[[4ic2]] – hXIAP RING domain <BR />
+
**[[4ic2]], [[8w5a]] – hXIAP RING domain <BR />
**[[4ic3]] – hXIAP RING domain (mutant) <BR />
**[[4ic3]] – hXIAP RING domain (mutant) <BR />
**[[2kna]] – hXIAP UBA domain - NMR <BR />
**[[2kna]] – hXIAP UBA domain - NMR <BR />
Line 702: Line 708:
**[[4j44]], [[4j45]], [[4j46]], [[4j47]], [[4j48]] - hXIAP BIR2 domain (mutant) + peptide<BR />
**[[4j44]], [[4j45]], [[4j46]], [[4j47]], [[4j48]] - hXIAP BIR2 domain (mutant) + peptide<BR />
**[[4kju]], [[4kjv]], [[4wvs]], [[4wvt]], [[4wvu]], [[4kjv]] - hXIAP BIR2 domain (mutant) + inhibitor<BR />
**[[4kju]], [[4kjv]], [[4wvs]], [[4wvt]], [[4wvu]], [[4kjv]] - hXIAP BIR2 domain (mutant) + inhibitor<BR />
-
**[[4hy0]], [[5c0k]], [[5c0l]], [[5c3h]], [[5c3k]], [[5c7a]], [[5c7b]], [[5c7c]], [[5c7d]], [[5c83]], [[5c84]], [[4kmp]], [[4wvs]], [[4wvt]], [[4wvu]], [[5oqm]], [[6h6q]], [[6h6r]], [[3hl5]], [[4hy0]] – hXIAP BIR3 domain + inhibitor <BR />
+
**[[3hl5]], [[4hy0]], [[4kmp]], [[4wvs]], [[4wvt]], [[4wvu]], [[5c0k]], [[5c0l]], [[5c3h]], [[5c3k]], [[5c7a]], [[5c7b]], [[5c7c]], [[5c7d]], [[5c83]], [[5c84]], [[5oqm]], [[5oqw]], [[6h6q]], [[6h6r]] – hXIAP BIR3 domain + inhibitor <BR />
**[[5m6e]], [[5m6f]], [[5m6h]], [[5m6l]], [[5m6m]], [[5m6n]], [[6ey2]] - hXIAP BIR3 domain (mutant) + inhibitor<BR />
**[[5m6e]], [[5m6f]], [[5m6h]], [[5m6l]], [[5m6m]], [[5m6n]], [[6ey2]] - hXIAP BIR3 domain (mutant) + inhibitor<BR />
-
**[[2jk7]], [[2vsl]], [[3g76]], [[4ec4]], [[3clx]], [[3cm2]], [[3cm7]], [[3eyl]], [[6ey2]] – hXIAP BIR3 domain + Smac mimetic <BR />
+
**[[2jk7]], [[2vsl]], [[3clx]], [[3cm2]], [[3cm7]], [[3eyl]], [[3g76]], [[4ec4]] – hXIAP BIR3 domain + Smac mimetic <BR />
 +
**[[8gh7]] - hXIAP BIR3 domain + peptide inhibitor<BR />
**[[3uw4]] - hXIAP BIR3 domain (mutant) + peptide<BR />
**[[3uw4]] - hXIAP BIR3 domain (mutant) + peptide<BR />
**[[5o6t]] – hXIAP RING domain + diubiquitin <BR />
**[[5o6t]] – hXIAP RING domain + diubiquitin <BR />
 +
**[[8w59]] – hXIAP RING domain + AsO3<BR />
*'''Ubiquitin protein ligase ZNRF'''
*'''Ubiquitin protein ligase ZNRF'''
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**[[5ywr]] – hUPL 1 RING domain + E2 N <BR />
**[[5ywr]] – hUPL 1 RING domain + E2 N <BR />
**[[4ufs]] – hUPL 3 ectodomain + R-spondin + LGR5 <br />
**[[4ufs]] – hUPL 3 ectodomain + R-spondin + LGR5 <br />
 +
**[[8g4y]] – hUPL 3 ectodomain + peptide<br />
**[[4cdj]] – mUPL 3 ectodomain <br />
**[[4cdj]] – mUPL 3 ectodomain <br />
**[[4c99]], [[4c9a]], [[4c9e]], [[4c9r]], [[4c9u]], [[4cdk]] – mUPL 3 ectodomain + R-spondin <br />
**[[4c99]], [[4c9a]], [[4c9e]], [[4c9r]], [[4c9u]], [[4cdk]] – mUPL 3 ectodomain + R-spondin <br />

Revision as of 10:59, 10 March 2024

3D Structures of ubiquitin protein ligase

Updated on 10-March-2024 - For a general description of the protein see Ubiquitin protein ligase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky

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