UDP-N-acetylglucosamine acyltransferase

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Current revision (10:24, 11 March 2024) (edit) (undo)
 
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The <scene name='74/749395/Cv/6'>substrate-binding site</scene> of LpxA interacts with the substrate UDP moiety and the Glc-NAc moiety. It contains a <scene name='74/749395/Cv/7'>His-Asp catalytic dyad</scene> where the His acts as a general base and Asp helps to orient the His for participation in the catalysis<ref>PMID:17434525</ref>.
The <scene name='74/749395/Cv/6'>substrate-binding site</scene> of LpxA interacts with the substrate UDP moiety and the Glc-NAc moiety. It contains a <scene name='74/749395/Cv/7'>His-Asp catalytic dyad</scene> where the His acts as a general base and Asp helps to orient the His for participation in the catalysis<ref>PMID:17434525</ref>.
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</StructureSection>
 
==3D structures of UDP-N-acetylglucosamine acyltransferase==
==3D structures of UDP-N-acetylglucosamine acyltransferase==
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[[UDP-N-acetylglucosamine acyltransferase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*UDP-N-acetylglucosamine acyltransferase
 
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**[[5f42]] – LpxA – ''Francicella novicida''<br />
 
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**[[5dem]], [[6ued]] – PaLpxA – ''Pseudomonas aeruginosa''<br />
 
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**[[4r36]] – BfLpxA – ''Bacterioides fragilis''<br />
 
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**[[4e6t]], [[4e6u]] – LpxA – ''Acinetobacter baumannii''<br />
 
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**[[3t57]] – LpxA – ''Arabidopsis thaliana''<br />
 
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**[[4eqy]] – LpxA – ''Burkholderia thailandensis''<br />
 
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**[[3r0s]] – LpxA – ''Campylobacter jejuni''<br />
 
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**[[3hsq]] – LiLpxA – ''Leptospira interrogans''<br />
 
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**[[2jf2]] – EcLpxA – ''Escherichia coli''<br />
 
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**[[1lxa]] – EcLpxA (mutant)<br />
 
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**[[1j2z]] – LpxA – ''Helicobacter pylori''<br />
 
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**[[5jxx]] – LpxA – ''Moraxella catarrhalis''<br />
 
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**[[6oss]] – LpxA – ''Proteus Mirabilis''<br />
 
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**[[5jxx]] – LpxA – ''Moraxella catarrhalis''<br />
 
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*UDP-N-acetylglucosamine acyltransferase complex
 
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**[[5dep]], [[5dg3]] – PaLpxA + UDP-GlcNAc derivative<br />
 
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**[[6ueg]], [[7oj6]], [[7ojp]], [[7ojq]], [[7ojw]], [[7ojy]], [[7ok1]], [[7ok2]], [[7oka]], [[7okb]] – PaLpxA + inhibitor<br />
 
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**[[4r37]] – BfLpxA + UDP-GlcNAc <br />
 
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**[[6uec]], [[6uee]], [[6ueg]] – PaLpxA + ligand<br />
 
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**[[4j09]] – EcLpxA + RJPXD33 peptide <br />
 
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**[[6p9p]] – EcLpxA + inhibitor<br />
 
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**[[2jf3]] – EcLpxA + UDP-GlcNAc <br />
 
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**[[3i3a]], [[3i3x]] – LiLpxA + sugar nucleotide<br />
 
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**[[2qiv]], [[2jf3]] – EcLpxA + sugar nucleotide<br />
 
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**[[6p9q]], [[6p9r]], [[6p9s]], [[6p9t]] - EcLpxA + inhibitor + UDP-myristoyl-GlcNAc<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

E. coli UDP-N-acetylglucosamine acyltransferase complex with UDP-Glc-NAC (PDB code 2jf3)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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