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Undecaprenyl pyrophosphate synthase

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== Structural highlights ==
== Structural highlights ==
-
The <scene name='59/591995/Cv/5'>active site</scene> of UPP (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.
+
The <scene name='59/591995/Cv/5'>active site</scene> of UPPS (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.
</StructureSection>
</StructureSection>
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*Undecaprenyl pyrophosphate synthase
*Undecaprenyl pyrophosphate synthase
-
**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />
+
**[[1f75]] – UPPS (mutant) – ''Micrococcus luteus''<br />
-
**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPP – ''Escherichia coli''<br />
+
**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPPS – ''Escherichia coli''<br />
-
**[[1jp3]] – EcUPP (mutant) <br />
+
**[[1jp3]] – EcUPPS (mutant) <br />
-
**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />
+
**[[2d2r]] – HpUPPS (mutant) – ''Helicobacter pylori''<br />
-
**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />
+
**[[2vg4]] – MtUPPS – ''Mycobacterium tuberculosis''<br />
-
**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br />
+
**[[5kh2]] – SpUPPS – ''Streptococcus pneumoniae''<br />
-
**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br />
+
**[[3wyi]] – SaUPPS - ''Staphylococcus aureus'' <br />
-
**[[5xk3]] – StUPP – ''Streptmyces''<br />
+
**[[5xk3]] – StUPPS – ''Streptmyces''<br />
-
**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />
+
**[[6acs]] - AbUPPS - ''Acinetobacter baumannii''<br />
-
**[[6loi]] - AbUPP - ''Enterococcus faecalis''<br />
+
**[[6loi]] - AbUPPS - ''Enterococcus faecalis''<br />
-
**[[7jli]] – BsUPP – ''Bacillus subtilis''<br />
+
**[[7jli]] – BsUPPS – ''Bacillus subtilis''<br />
*Undecaprenyl pyrophosphate synthase complexes
*Undecaprenyl pyrophosphate synthase complexes
-
**[[1ueh]] – EcUPP + Mg + SO4 + triton<br />
+
**[[1ueh]] – EcUPPS + Mg + SO4 + triton<br />
-
**[[1v7u]] – EcUPP + FPP <br />
+
**[[1v7u]] – EcUPPS + FPP <br />
-
**[[4u82]] – EcUPP + Mg + FPP derivative<br />
+
**[[4u82]] – EcUPPS + Mg + FPP derivative<br />
-
**[[1x06]] – EcUPP + Mg + FPP analog + IPP<br />
+
**[[1x06]] – EcUPPS + Mg + FPP analog + IPP<br />
-
**[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br />
+
**[[1x08]] – EcUPPS (mutant) + Mg + FPP analog + IPP<br />
-
**[[1x07]] – EcUPP + Mg + PO4 + IPP<br />
+
**[[1x07]] – EcUPPS + Mg + PO4 + IPP<br />
-
**[[1x09]] – EcUPP (mutant) + Mg + IPP<br />
+
**[[1x09]] – EcUPPS (mutant) + Mg + IPP<br />
**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />
**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />
-
**[[5cqj]], [[5zhe]] – EcUPP + inhibitor <br />
+
**[[5cqj]], [[5zhe]] – EcUPPS + inhibitor <br />
-
**[[5kh4]] – SpUPP + FPP <br />
+
**[[5kh4]] – SpUPPS + FPP <br />
-
**[[5kh5]] – SpUPP + inhibitor <br />
+
**[[5kh5]] – SpUPPS + inhibitor <br />
-
**[[2dtn]] – HpUPP + pyrophosphate<br />
+
**[[2dtn]] – HpUPPS + pyrophosphate<br />
-
**[[3ugs]] - UPP + FPP analog – ''Campylobacter jejuni''<br />
+
**[[3ugs]] - UPPS + FPP analog – ''Campylobacter jejuni''<br />
-
**[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br />
+
**[[2vg2]] – MtUPPS + Pi + PPi + methyl butenyl diphosphate <br />
-
**[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br />
+
**[[2vg3]] – MtUPPS + Pi + Mg + geranyl diphosphate <br />
-
**[[5xk8]] – StUPP + GPP <br />
+
**[[5xk8]] – StUPPS + GPP <br />
-
**[[5xk6]] – StUPP + IPP <br />
+
**[[5xk6]] – StUPPS + IPP <br />
-
**[[5xk7]] – StUPP + DMAPP <br />
+
**[[5xk7]] – StUPPS + DMAPP <br />
-
**[[5xk9]] – StUPP + GSPP + DMAPP <br />
+
**[[5xk9]] – StUPPS + GSPP + DMAPP <br />
-
**[[6szg]], [[6szh]] - AbUPP + inhibitor<br />
+
**[[6szg]], [[6szh]] - AbUPPS + inhibitor<br />
-
**[[7jljj]], [[7jlm]], [[7jlr]] – BsUPP + inhibitor <br />
+
**[[7jlj]], [[7jlm]], [[7jlr]] – BsUPPS + inhibitor <br />
 +
 
 +
*Nuclear UPPS or NUS1 or dehydrodolichyl diphosphate synthase complex subunit NUS1
 +
 
 +
**[[6z1n]], [[7pay]] – hNUS1 + hDHDDS<br />
 +
**[[6w2l]] – hNUS1 + hDHDDS + IPP<br />
 +
**[[7pax]] – hNUS1 + hDHDDS + FSPP + IPP<br />
 +
**[[7pb0]] – hNUS1 + hDHDDS + GGSPP + ISPP<br />
 +
**[[6jcn]] – yNUS1 - yeast<br />
}}
}}

Revision as of 11:37, 11 March 2024

Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07).

Drag the structure with the mouse to rotate

3D structures of undecaprenyl pyrophosphate synthase

Updated on 11-March-2024

References

  1. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
  2. ↑ Grabińska KA, Park EJ, Sessa WC. cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases. J Biol Chem. 2016 Aug 26;291(35):18582-90. PMID:27402831 doi:10.1074/jbc.R116.739490
  3. ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
  4. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200

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