1qv4
From Proteopedia
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[[Image:1qv4.gif|left|200px]] | [[Image:1qv4.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_1qv4| PDB=1qv4 | SCENE= }} | |
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'''B-DNA Dodecamer CGTGAATTCACG complexed with minor groove binder methylproamine''' | '''B-DNA Dodecamer CGTGAATTCACG complexed with minor groove binder methylproamine''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QV4 OCA]. | |
==Reference== | ==Reference== | ||
In vitro studies with methylproamine: a potent new radioprotector., Martin RF, Broadhurst S, Reum ME, Squire CJ, Clark GR, Lobachevsky PN, White JM, Clark C, Sy D, Spotheim-Maurizot M, Kelly DP, Cancer Res. 2004 Feb 1;64(3):1067-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14871839 14871839] | In vitro studies with methylproamine: a potent new radioprotector., Martin RF, Broadhurst S, Reum ME, Squire CJ, Clark GR, Lobachevsky PN, White JM, Clark C, Sy D, Spotheim-Maurizot M, Kelly DP, Cancer Res. 2004 Feb 1;64(3):1067-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14871839 14871839] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Clark, G R.]] | [[Category: Clark, G R.]] | ||
[[Category: Squire, C J.]] | [[Category: Squire, C J.]] | ||
| - | [[Category: | + | [[Category: B-dna]] |
| - | [[Category: | + | [[Category: Minor groove binder]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:44:19 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:44, 3 May 2008
B-DNA Dodecamer CGTGAATTCACG complexed with minor groove binder methylproamine
Overview
New analogues of the minor groove binding ligand Hoechst 33342 have been investigated in an attempt to improve radioprotective activity. The synthesis, DNA binding, and in vitro radioprotective properties of methylproamine, the most potent derivative, are reported. Experiments with V79 cells have shown that methylproamine is approximately 100-fold more potent than the classical aminothiol radioprotector WR1065. The crystal structures of methylproamine and proamine complexes with the dodecamer d(CGCGAATTCGCG)(2) confirm that the new analogues also are minor groove binders. It is proposed that the DNA-bound methylproamine ligand acts as a reducing agent by an electron transfer mechanism, repairing transient radiation-induced oxidizing species on DNA.
About this Structure
Full crystallographic information is available from OCA.
Reference
In vitro studies with methylproamine: a potent new radioprotector., Martin RF, Broadhurst S, Reum ME, Squire CJ, Clark GR, Lobachevsky PN, White JM, Clark C, Sy D, Spotheim-Maurizot M, Kelly DP, Cancer Res. 2004 Feb 1;64(3):1067-70. PMID:14871839 Page seeded by OCA on Sat May 3 06:44:19 2008
