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8ptl

From Proteopedia

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m (Protected "8ptl" [edit=sysop:move=sysop])
Current revision (13:16, 13 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ptl is ON HOLD until Paper Publication
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==human PHOX2B C-terminal domain including the polyA fragment at 278K==
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<StructureSection load='8ptl' size='340' side='right'caption='[[8ptl]]' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ptl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PTL FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ptl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ptl OCA], [https://pdbe.org/8ptl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ptl RCSB], [https://www.ebi.ac.uk/pdbsum/8ptl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ptl ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PHX2B_HUMAN PHX2B_HUMAN] Neuroblastoma;Congenital central hypoventilation syndrome;Hirschsprung disease-ganglioneuroblastoma syndrome;Haddad syndrome. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/PHX2B_HUMAN PHX2B_HUMAN] Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Anton R]]
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[[Category: Babu M]]
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[[Category: Cabrita EJ]]
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[[Category: Felix S]]
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[[Category: Oroz J]]
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[[Category: Pantoja-Uceda D]]
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[[Category: Tinnefeld P]]
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[[Category: Trevino MA]]
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[[Category: Vera AM]]
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[[Category: Zweckstetter M]]

Current revision

human PHOX2B C-terminal domain including the polyA fragment at 278K

PDB ID 8ptl

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OCA

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