1kwh

<table><tr><td colspan='2'>[[1kwh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingomonas_sp._a1 Sphingomonas sp. a1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KWH FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">algQ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90322 Sphingomonas sp. A1])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1kwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwh OCA], [http://pdbe.org/1kwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kwh RCSB], [http://www.ebi.ac.uk/pdbsum/1kwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kwh ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Sphingomonas sp. A1 possesses a high molecular mass (average 25,700 Da) alginate uptake system mediated by a novel pit-dependent ABC transporter. The X-ray crystallographic structure of AlgQ2 (57,200 Da), an alginate-binding protein in the system, was determined by the multiple isomorphous replacement method and refined at 2.0 A resolution with a final R-factor of 18.3% for 15 to 2.0 A resolution data. The refined structure of AlgQ2 was comprised of 492 amino acid residues, 172 water molecules, and one calcium ion. AlgQ2 was composed of two globular domains with a deep cleft between them, which is expected to be the alginate-binding site. The overall structure is basically similar to that of maltose/maltodextrin-binding protein, except for the presence of an N2-subdomain. The entire calcium ion-binding site is similar to the site in the EF-hand motif, but comprises a ten residue loop. This calcium ion-binding site is about 40 A away from the alginate-binding site.

Crystal structure of AlgQ2, a macromolecule (alginate)-binding protein of Sphingomonas sp. A1 at 2.0A resolution.,Momma K, Mikami B, Mishima Y, Hashimoto W, Murata K J Mol Biol. 2002 Mar 8;316(5):1051-9. PMID:11884143<ref>PMID:11884143</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1kwh" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Sphingomonas sp. a1]]

[[Category: Hashimoto, W]]

[[Category: Mikami, B]]

[[Category: Mishima, Y]]

[[Category: Momma, K]]

[[Category: Murata, K]]

[[Category: Protein binding]]