1qwf

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[[Image:1qwf.jpg|left|200px]]
[[Image:1qwf.jpg|left|200px]]
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{{Structure
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|PDB= 1qwf |SIZE=350|CAPTION= <scene name='initialview01'>1qwf</scene>
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The line below this paragraph, containing "STRUCTURE_1qwf", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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|GENE= CHICKEN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11876 Avian sarcoma virus])
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|DOMAIN=
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{{STRUCTURE_1qwf| PDB=1qwf | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qwf OCA], [http://www.ebi.ac.uk/pdbsum/1qwf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qwf RCSB]</span>
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'''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12'''
'''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12'''
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[[Category: Rickles, R J.]]
[[Category: Rickles, R J.]]
[[Category: Schreiber, S L.]]
[[Category: Schreiber, S L.]]
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[[Category: class i ligand complex]]
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[[Category: Class i ligand complex]]
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[[Category: src sh3 domain]]
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[[Category: Src sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:46:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:19:54 2008''
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Revision as of 03:46, 3 May 2008

Image:1qwf.jpg

Template:STRUCTURE 1qwf

C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12


Overview

Two dodecapeptides belonging to distinct classes of Src homology 3 (SH3) ligands and selected from biased phage display libraries were used to investigate interactions between a specificity pocket in the Src SH3 domain and ligant residues flanking the proline-rich core. The solution structures of c-Src SH3 complexed with these peptides were solved by NMR. In addition to proline-rich, polyproline type II helix-forming core, the class I and II ligands each possesses a flanking sequence that occupies a large pocket between the RT and n-Src loops of the SH3 domain. Structural and mutational analyses illustrate how the two classes of SH3 ligands exploit a specificity pocket on the receptor differently to increase binding affinity and specificity.

About this Structure

1QWF is a Single protein structure of sequence from Avian sarcoma virus. Full crystallographic information is available from OCA.

Reference

Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:8618911 Page seeded by OCA on Sat May 3 06:46:39 2008

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