1wvh
From Proteopedia
(Difference between revisions)
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<StructureSection load='1wvh' size='340' side='right'caption='[[1wvh]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='1wvh' size='340' side='right'caption='[[1wvh]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wvh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1wvh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WVH FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wvh OCA], [https://pdbe.org/1wvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wvh RCSB], [https://www.ebi.ac.uk/pdbsum/1wvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wvh ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wvh OCA], [https://pdbe.org/1wvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wvh RCSB], [https://www.ebi.ac.uk/pdbsum/1wvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wvh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TENS1_CHICK TENS1_CHICK] May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Plays a role in cell polarization and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton.[UniProtKB:Q9HBL0] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wvh ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wvh ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Tensin is a cytoskeletal protein that links integrins to the actin cytoskeleton at sites of cell-matrix adhesion. Here we describe the crystal structure of the phosphotyrosine-binding (PTB) domain of tensin1, and show that it binds integrins in an NPxY-dependent fashion. Alanine mutagenesis of both the PTB domain and integrin tails supports a model of integrin binding similar to that of the PTB-like domain of talin. However, we also show that phosphorylation of the NPxY tyrosine, which disrupts talin binding, has a negligible effect on tensin binding. This suggests that tyrosine phosphorylation of integrin, which occurs during the maturation of focal adhesions, could act as a switch to promote the migration of tensin-integrin complexes into fibronectin-mediated fibrillar adhesions. | ||
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| - | Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions.,McCleverty CJ, Lin DC, Liddington RC Protein Sci. 2007 Jun;16(6):1223-9. Epub 2007 May 1. PMID:17473008<ref>PMID:17473008</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1wvh" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Gallus gallus]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liddington | + | [[Category: Liddington RC]] |
| - | [[Category: McCleverty | + | [[Category: McCleverty CJ]] |
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Current revision
Crystal structure of tensin1 PTB domain
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