2baw
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2baw' size='340' side='right'caption='[[2baw]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2baw' size='340' side='right'caption='[[2baw]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2baw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2baw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BAW FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2baw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2baw OCA], [https://pdbe.org/2baw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2baw RCSB], [https://www.ebi.ac.uk/pdbsum/2baw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2baw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2baw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2baw OCA], [https://pdbe.org/2baw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2baw RCSB], [https://www.ebi.ac.uk/pdbsum/2baw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2baw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 20: | Line 20: | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2baw ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2baw ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis. We report the crystal structure of the PPAR delta ligand-binding domain (LBD) bound to either the FA eicosapentaenoic acid (EPA) or the synthetic fibrate GW2433. The carboxylic acids of EPA and GW2433 interact directly with the activation function 2 (AF-2) helix. The hydrophobic tail of EPA adopts two distinct conformations within the large hydrophobic cavity. GW2433 occupies essentially the same space as EPA bound in both conformations. These structures provide molecular insight into the propensity for PPARs to interact with a variety of synthetic and natural compounds, including FAs that vary in both chain length and degree of saturation. | ||
| - | |||
| - | Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.,Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV Mol Cell. 1999 Mar;3(3):397-403. PMID:10198642<ref>PMID:10198642</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2baw" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| Line 36: | Line 27: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Alphey | + | [[Category: Alphey MS]] |
| - | [[Category: Bjorkling | + | [[Category: Bjorkling F]] |
| - | [[Category: Buetow | + | [[Category: Buetow L]] |
| - | [[Category: Ferguson | + | [[Category: Ferguson MAJ]] |
| - | [[Category: Fyffe | + | [[Category: Fyffe SA]] |
| - | [[Category: Hunter | + | [[Category: Hunter WN]] |
| - | [[Category: Smith | + | [[Category: Smith TK]] |
| - | [[Category: Sorensen | + | [[Category: Sorensen MD]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Human Nuclear Receptor-Ligand Complex 1
| |||||||||||
Categories: Homo sapiens | Large Structures | Alphey MS | Bjorkling F | Buetow L | Ferguson MAJ | Fyffe SA | Hunter WN | Smith TK | Sorensen MD
