1t5q

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Revision as of 17:14, 12 November 2007

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Solution Structure of GIP(1-30)amide in TFE/Water

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Glucose-dependent insulinotropic polypeptide is an incretin hormone that, stimulates insulin secretion and reduces postprandial glycaemic, excursions. The glucose-dependent action of GIP on pancreatic beta-cells, has attracted attention towards its exploitation as a potential drug for, type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine, the three-dimensional structure of the peptide. Therefore, to understand, the basic structural requirements for the biological activity of GIP, the, solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular, modelling. The structure is characterised by a full length alpha-helical, conformation between residues F(6) and A(28). This structural information, could play an important role in the design of therapeutic agents based, upon GIP receptor agonists.

Disease

Known diseases associated with this structure: Pituitary ACTH-secreting adenoma OMIM:[139360], Ventricular tachycardia, idiopathic OMIM:[139360]

About this Structure

1T5Q is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide., Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP, Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6. PMID:15522230

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