2ela

<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELA FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2elb|2elb]]</div></td></tr>

[[https://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>

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== Publication Abstract from PubMed ==

APPL1 interacts with adiponectin receptors and other important signaling molecules. It contains a BAR and a PH domain near its N terminus, and the two domains may function as a unit (BAR-PH domain). We report here the crystal structures of the BAR-PH and PTB domains of human APPL1. The structures reveal novel features for BAR domain dimerization and for the interactions between the BAR and PH domains. The BAR domain dimer of APPL1 contains two four-helical bundles, whereas other BAR domain dimers have only three helices in each bundle. The PH domain is located at the opposite ends of the BAR domain dimer. Yeast two-hybrid assays confirm the interactions between the BAR and PH domains. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling.

Crystal structures of the BAR-PH and PTB domains of human APPL1.,Li J, Mao X, Dong LQ, Liu F, Tong L Structure. 2007 May;15(5):525-33. PMID:17502098<ref>PMID:17502098</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2ela" style="background-color:#fffaf0;"></div>

[[Category: Human]]

[[Category: Dong, L Q]]

[[Category: Li, J]]

[[Category: Liu, F]]

[[Category: Mao, X]]

[[Category: Tong, L]]

[[Category: Ptb domain]]