2z1p

<table><tr><td colspan='2'>[[2z1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z1P FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z1p OCA], [http://pdbe.org/2z1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z1p RCSB], [http://www.ebi.ac.uk/pdbsum/2z1p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z1p ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

We have determined the crystal structure of the ligand binding segment of the Enterococcus faecalis collagen binding MSCRAMM ACE (microbial surface components recognizing adhesive matrix molecules adhesin of collagen from enterococci). This segment is composed of two subdomains, N(1) and N(2), each adopting an IgG-like fold and forming a putative collagen binding surface at the interface between the two subdomains. This structure is very similar to that recently reported for CNA, the collagen binding MSCRAMM of Staphylococcus aureus, for which a unique ligand binding mechanism called the Collagen Hug was proposed. We suggest that ACE binds collagen by a similar mechanism and present the first biochemical evidence for this binding model. Replacing residues in the putative collagen binding trench of ACE N(2) with Ala residues affected collagen binding. A closed conformation of ACE stabilized by an engineered disulfide bond is unable to bind collagen. Finally, the importance of the residues in the N(2) extension in stabilizing the MSCRAMM-ligand complex is demonstrated by selected point and truncation mutations.

The Enterococcus faecalis MSCRAMM ACE binds its ligand by the Collagen Hug model.,Liu Q, Ponnuraj K, Xu Y, Ganesh VK, Sillanpaa J, Murray BE, Narayana SV, Hook M J Biol Chem. 2007 Jul 6;282(27):19629-37. Epub 2007 Mar 28. PMID:17392280<ref>PMID:17392280</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]

[[Category: Ponnuraj, K]]

[[Category: Enterococcus faecali]]