2zwn

<table><tr><td colspan='2'>[[2zwn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Metagenomes Metagenomes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZWN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZWN FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2O:CU-O-CU+LINKAGE'>C2O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zwn OCA], [http://pdbe.org/2zwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zwn RCSB], [http://www.ebi.ac.uk/pdbsum/2zwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zwn ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

A multi-copper protein with two cupredoxin-like domains was identified from our in-house metagenomic database. The recombinant protein, mgLAC, contained four copper ions/subunits, oxidized various phenolic and non-phenolic substrates, and had spectroscopic properties similar to common laccases. X-ray structure analysis revealed a homotrimeric architecture for this enzyme, which resembles nitrite reductase (NIR). However, a difference in copper coordination was found at the domain interface. mgLAC contains a T2/T3 tri-nuclear copper cluster at this site, whereas a mononuclear T2 copper occupies this position in NIR. The trimer is thus an essential part of the architecture of two-domain multi-copper proteins, and mgLAC may be an evolutionary precursor of NIR.

X-ray structure of a two-domain type laccase: a missing link in the evolution of multi-copper proteins.,Komori H, Miyazaki K, Higuchi Y FEBS Lett. 2009 Apr 2;583(7):1189-95. Epub 2009 Mar 11. PMID:19285076<ref>PMID:19285076</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2zwn" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Higuchi, Y]]

[[Category: Komori, H]]

[[Category: Miyazaki, K]]

[[Category: Oxidoreductase]]