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== Function ==
== Function ==
[https://www.uniprot.org/uniprot/Q5ZS45_LEGPH Q5ZS45_LEGPH]
[https://www.uniprot.org/uniprot/Q5ZS45_LEGPH Q5ZS45_LEGPH]
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<div style="background-color:#fffaf0;">
 
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== Publication Abstract from PubMed ==
 
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The Dot/Icm type IVB secretion system (T4BSS) is a pivotal determinant of Legionella pneumophila pathogenesis. L. pneumophila translocate more than 100 effector proteins into host cytoplasm using Dot/Icm T4BSS, modulating host cellular functions to establish a replicative niche within host cells. The T4BSS core complex spanning the inner and outer membranes is thought to be made up of at least five proteins: DotC, DotD, DotF, DotG and DotH. DotH is the outer membrane protein; its targeting depends on lipoproteins DotC and DotD. However, the core complex structure and assembly mechanism are still unknown. Here, we report the crystal structure of DotD at 2.0 A resolution. The structure of DotD is distinct from that of VirB7, the outer membrane lipoprotein of the type IVA secretion system. In contrast, the C-terminal domain of DotD is remarkably similar to the N-terminal subdomain of secretins, the integral outer membrane proteins that form substrate conduits for the type II and the type III secretion systems (T2SS and T3SS). A short beta-segment in the otherwise disordered N-terminal region, located on the hydrophobic cleft of the C-terminal domain, is essential for outer membrane targeting of DotH and Dot/Icm T4BSS core complex formation. These findings uncover an intriguing link between T4BSS and T2SS/T3SS.
 
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Crystal structure of Legionella DotD: insights into the relationship between type IVB and type II/III secretion systems.,Nakano N, Kubori T, Kinoshita M, Imada K, Nagai H PLoS Pathog. 2010 Oct 7;6(10). pii: e1001129. PMID:20949065<ref>PMID:20949065</ref>
 
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
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<div class="pdbe-citations 3ady" style="background-color:#fffaf0;"></div>
 
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== References ==
 
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<references/>
 
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</StructureSection>
</StructureSection>

Current revision

Crystal structure of DotD from Legionella

PDB ID 3ady

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