3alr
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Q4QRE8_DANRE Q4QRE8_DANRE] | [https://www.uniprot.org/uniprot/Q4QRE8_DANRE Q4QRE8_DANRE] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Nanos is an RNA-binding protein that is involved in the development and maintenance of germ cells. In combination with Pumilio, Nanos binds to the 3' untranslated region of a messenger RNA and represses its translation. Nanos has two conserved Cys-Cys-His-Cys zinc-finger motifs that are indispensable for its function. In this study, we have determined the crystal structure of the zinc-finger domain of zebrafish Nanos, for the first time revealing that Nanos adopts a novel zinc-finger structure. In addition, Nanos has a conserved basic surface that is directly involved in RNA binding. Our results provide the structural basis for further studies to clarify Nanos function. | ||
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| - | Crystal structure of zinc-finger domain of Nanos and its functional implications.,Hashimoto H, Hara K, Hishiki A, Kawaguchi S, Shichijo N, Nakamura K, Unzai S, Tamaru Y, Shimizu T, Sato M EMBO Rep. 2010 Nov;11(11):848-53. Epub 2010 Oct 15. PMID:20948543<ref>PMID:20948543</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 3alr" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of Nanos
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Categories: Danio rerio | Large Structures | Hara K | Hashimoto H | Hishiki A | Kawaguchi S | Nakamura K | Sato M | Shichijo N | Shimizu T | Tamaru Y | Unzai S
