5w7g

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Current revision (14:14, 13 March 2024) (edit) (undo)
 
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<SX load='5w7g' size='340' side='right' viewer='molstar' caption='[[5w7g]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
<SX load='5w7g' size='340' side='right' viewer='molstar' caption='[[5w7g]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5w7g]] is a 44 chain structure with sequence from [http://en.wikipedia.org/wiki/Acidianus_filamentous_virus_1 Acidianus filamentous virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W7G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5W7G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5w7g]] is a 44 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidianus_filamentous_virus_1 Acidianus filamentous virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W7G FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5w7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w7g OCA], [http://pdbe.org/5w7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w7g RCSB], [http://www.ebi.ac.uk/pdbsum/5w7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w7g ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w7g OCA], [https://pdbe.org/5w7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w7g RCSB], [https://www.ebi.ac.uk/pdbsum/5w7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w7g ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/CAPS1_AFV1Y CAPS1_AFV1Y] Self-assembles to form a helical, filamentous nucleocapsid mesuring 900 nm in length and 24 nm in width (Probable) (PubMed:19934032). Together with capsid protein 2, wraps arounds the DNA and maintains it in an A-form (Probable). Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).<ref>PMID:19934032</ref> <ref>PMID:32759221</ref>
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Biological membranes create compartments, and are usually formed by lipid bilayers. However, in hyperthermophilic archaea that live optimally at temperatures above 80 degrees C the membranes are monolayers which resemble fused bilayers. Many double-stranded DNA viruses which parasitize such hosts, including the filamentous virus AFV1 of Acidianus hospitalis, are enveloped with a lipid-containing membrane. Using cryo-EM, we show that the membrane in AFV1 is a ~2 nm-thick monolayer, approximately half the expected membrane thickness, formed by host membrane-derived lipids which adopt a U-shaped 'horseshoe' conformation. We hypothesize that this unusual viral envelope structure results from the extreme curvature of the viral capsid, as 'horseshoe' lipid conformations favor such curvature and host membrane lipids that permit horseshoe conformations are selectively recruited into the viral envelope. The unusual envelope found in AFV1 also has many implications for biotechnology, since this membrane can survive the most aggressive conditions involving extremes of temperature and pH.
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Model for a novel membrane envelope in a filamentous hyperthermophilic virus.,Kasson P, DiMaio F, Yu X, Lucas-Staat S, Krupovic M, Schouten S, Prangishvili D, Egelman EH Elife. 2017 Jun 22;6. pii: e26268. doi: 10.7554/eLife.26268. PMID:28639939<ref>PMID:28639939</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5w7g" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
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[[Category: Acidianus filamentous virus 1]]
[[Category: Acidianus filamentous virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: DiMaio, F]]
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[[Category: DiMaio F]]
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[[Category: Egelman, E]]
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[[Category: Egelman E]]
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[[Category: Kasson, P]]
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[[Category: Kasson P]]
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[[Category: Krupovic, M]]
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[[Category: Krupovic M]]
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[[Category: Lucas-Staat, S]]
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[[Category: Lucas-Staat S]]
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[[Category: Prangishvili, D]]
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[[Category: Prangishvili D]]
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[[Category: Schouten, S]]
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[[Category: Schouten S]]
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[[Category: Yu, X]]
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[[Category: Yu X]]
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[[Category: A-form dna]]
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[[Category: Afv1]]
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[[Category: Filamentous virus]]
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[[Category: Hyperthermophile]]
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[[Category: Virus]]
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Current revision

An envelope of a filamentous hyperthermophilic virus carries lipids in a horseshoe conformation

5w7g, resolution 4.50Å

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OCA

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