6br9

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Current revision (14:23, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6br9' size='340' side='right'caption='[[6br9]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='6br9' size='340' side='right'caption='[[6br9]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6br9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fowpn Fowpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BR9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6br9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fowlpox_virus_strain_NVSL Fowlpox virus strain NVSL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BR9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OU:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+(~{Z})-octadec-9-enoate'>6OU</scene>, <scene name='pdbligand=PGV:(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+(11E)-OCTADEC-11-ENOATE'>PGV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FPV170 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=928301 FOWPN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OU:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+(~{Z})-octadec-9-enoate'>6OU</scene>, <scene name='pdbligand=PGV:(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+(11E)-OCTADEC-11-ENOATE'>PGV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6br9 OCA], [http://pdbe.org/6br9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6br9 RCSB], [http://www.ebi.ac.uk/pdbsum/6br9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6br9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6br9 OCA], [https://pdbe.org/6br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6br9 RCSB], [https://www.ebi.ac.uk/pdbsum/6br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6br9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A6_FOWPN A6_FOWPN]] Plays an essential role in immature virion (IV) to mature virion (MV) transition.
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[https://www.uniprot.org/uniprot/A6_FOWPN A6_FOWPN] Plays an essential role in immature virion (IV) to mature virion (MV) transition.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cellular membranes are maintained as closed compartments, broken up only transiently during membrane reorganization or lipid transportation. However, open-ended membranes, likely derived from scissions of the endoplasmic reticulum, persist in vaccinia virus-infected cells during the assembly of the viral envelope. A group of viral membrane assembly proteins (VMAPs) were identified as essential for this process. To understand the mechanism of VMAPs, we determined the 2.2-A crystal structure of the largest member, named A6, which is a soluble protein with two distinct domains. The structure of A6 displays a novel protein fold composed mainly of alpha helices. The larger C-terminal domain forms a unique cage that encloses multiple glycerophospholipids with a lipid bilayer-like configuration. The smaller N-terminal domain does not bind lipid but negatively affects lipid binding by A6. Mutations of key hydrophobic residues lining the lipid-binding cage disrupt lipid binding and abolish viral replication. Our results reveal a protein modality for enclosing the lipid bilayer and provide molecular insight into a viral machinery involved in generating and/or stabilizing open-ended membranes.
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Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.,Pathak PK, Peng S, Meng X, Han Y, Zhang B, Zhang F, Xiang Y, Deng J Proc Natl Acad Sci U S A. 2018 Jun 18. pii: 1805855115. doi:, 10.1073/pnas.1805855115. PMID:29915071<ref>PMID:29915071</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6br9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fowpn]]
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[[Category: Fowlpox virus strain NVSL]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Deng, J]]
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[[Category: Deng J]]
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[[Category: Pathak, P]]
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[[Category: Pathak P]]
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[[Category: Peng, S]]
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[[Category: Peng S]]
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[[Category: A6]]
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[[Category: Lipid binding]]
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[[Category: Lipid binding protein]]
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[[Category: Membrane biogenesis]]
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[[Category: Poxvirus]]
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Current revision

Structure of A6 reveals a novel lipid transporter

PDB ID 6br9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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