6by7

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Current revision (14:24, 13 March 2024) (edit) (undo)
 
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<SX load='6by7' size='340' side='right' viewer='molstar' caption='[[6by7]], [[Resolution|resolution]] 7.50&Aring;' scene=''>
<SX load='6by7' size='340' side='right' viewer='molstar' caption='[[6by7]], [[Resolution|resolution]] 7.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6by7]] is a 118 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BY7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BY7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6by7]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BY7 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6by7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6by7 OCA], [http://pdbe.org/6by7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6by7 RCSB], [http://www.ebi.ac.uk/pdbsum/6by7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6by7 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6by7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6by7 OCA], [https://pdbe.org/6by7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6by7 RCSB], [https://www.ebi.ac.uk/pdbsum/6by7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6by7 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
 
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== Publication Abstract from PubMed ==
 
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Building upon DNA origami technology, we introduce a method to reconstitute a single membrane protein into a self-assembled DNA nanobarrel that scaffolds a nanodisc-like lipid environment. Compared with the membrane-scaffolding-protein nanodisc technique, our approach gives rise to defined stoichiometry, controlled sizes, as well as enhanced stability and homogeneity in membrane protein reconstitution. We further demonstrate potential applications of the DNA nanobarrels in the structural analysis of membrane proteins.
 
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Folding DNA into a Lipid-Conjugated Nanobarrel for Controlled Reconstitution of Membrane Proteins.,Dong Y, Chen S, Zhang S, Sodroski J, Yang Z, Liu D, Mao Y Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2072-2076. doi: 10.1002/anie.201710147., Epub 2018 Jan 9. PMID:29266648<ref>PMID:29266648</ref>
 
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
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</div>
 
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<div class="pdbe-citations 6by7" style="background-color:#fffaf0;"></div>
 
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== References ==
 
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<references/>
 
__TOC__
__TOC__
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, S]]
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[[Category: Synthetic construct]]
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[[Category: Dong, Y]]
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[[Category: Chen S]]
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[[Category: Liu, D]]
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[[Category: Dong Y]]
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[[Category: Mao, Y]]
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[[Category: Liu D]]
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[[Category: Sodroski, J]]
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[[Category: Mao Y]]
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[[Category: Yang, Z]]
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[[Category: Sodroski J]]
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[[Category: Zhang, S]]
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[[Category: Yang Z]]
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[[Category: Dna]]
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[[Category: Zhang S]]
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[[Category: Dna nano-barrel dna origami dna assembly]]
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Current revision

Folding DNA into a lipid-conjugated nano-barrel for controlled reconstitution of membrane proteins

6by7, resolution 7.50Å

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