1qy6

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[[Image:1qy6.jpg|left|200px]]
[[Image:1qy6.jpg|left|200px]]
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{{Structure
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|PDB= 1qy6 |SIZE=350|CAPTION= <scene name='initialview01'>1qy6</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1qy6", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span>
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{{STRUCTURE_1qy6| PDB=1qy6 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qy6 OCA], [http://www.ebi.ac.uk/pdbsum/1qy6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qy6 RCSB]</span>
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'''Structue of V8 Protease from Staphylococcus aureus'''
'''Structue of V8 Protease from Staphylococcus aureus'''
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[[Category: Leduc, Y.]]
[[Category: Leduc, Y.]]
[[Category: Prasad, L.]]
[[Category: Prasad, L.]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:50:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:20:36 2008''
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Revision as of 03:50, 3 May 2008

Image:1qy6.jpg

Template:STRUCTURE 1qy6

Structue of V8 Protease from Staphylococcus aureus


Overview

V8 protease, an extracellular protease of Staphylococcus aureus, is related to the pancreatic serine proteases. The enzyme cleaves peptide bonds exclusively on the carbonyl side of aspartate and glutamate residues. Unlike the pancreatic serine proteases, V8 protease possesses no disulfide bridges. This is a major evolutionary difference, as all pancreatic proteases have at least two disulfide bridges. The structure of V8 protease shows structural similarity with several other serine proteases, specifically the epidermolytic toxins A and B from S. aureus and trypsin, in which the conformation of the active site is almost identical. V8 protease is also unique in that the positively charged N-terminus is involved in determining the substrate-specificity of the enzyme.

About this Structure

1QY6 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

The structure of a universally employed enzyme: V8 protease from Staphylococcus aureus., Prasad L, Leduc Y, Hayakawa K, Delbaere LT, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):256-9. Epub 2004, Jan 23. PMID:14747701 Page seeded by OCA on Sat May 3 06:50:44 2008

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