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6dt0

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Current revision (14:36, 13 March 2024) (edit) (undo)
 
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<SX load='6dt0' size='340' side='right' viewer='molstar' caption='[[6dt0]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<SX load='6dt0' size='340' side='right' viewer='molstar' caption='[[6dt0]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCU08166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [http://pdbe.org/6dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [https://pdbe.org/6dt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [https://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q7S4I4_NEUCR Q7S4I4_NEUCR]
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Calcium transport plays an important role in regulating mitochondrial physiology and pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion channel that is the primary mediator for calcium uptake into the mitochondrial matrix. Here we present the cryo-electron microscopy structure of the full-length MCU from Neurospora crassa to an overall resolution of ~3.7 A. Our structure reveals a tetrameric architecture, with the soluble and transmembrane domains adopting different symmetric arrangements within the channel. The conserved W-D-Phi-Phi-E-P-V-T-Y sequence motif of MCU pore forms a selectivity filter comprising two acidic rings separated by one helical turn along the central axis of the channel pore. The structure combined with mutagenesis gives insight into the basis of calcium recognition.
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Cryo-EM structure of a mitochondrial calcium uniporter.,Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988<ref>PMID:29954988</ref>
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==See Also==
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*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6dt0" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Chrysonilia crassa]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Herzik, M A.J]]
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[[Category: Neurospora crassa]]
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[[Category: Lander, G C]]
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[[Category: Herzik MAJ]]
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[[Category: Lee, S Y]]
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[[Category: Lander GC]]
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[[Category: Wu, M]]
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[[Category: Lee S-Y]]
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[[Category: Yin, Y]]
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[[Category: Wu M]]
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[[Category: Yoo, J]]
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[[Category: Yin Y]]
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[[Category: Calcium uptake]]
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[[Category: Yoo J]]
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[[Category: Calcium-selective ion channel]]
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[[Category: Mitochondrial calcium uniporter]]
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[[Category: Transport protein]]
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[[Category: Uniporter]]
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Current revision

Cryo-EM structure of a mitochondrial calcium uniporter

6dt0, resolution 3.70Å

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