6dt0

<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCU08166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [http://pdbe.org/6dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Calcium transport plays an important role in regulating mitochondrial physiology and pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion channel that is the primary mediator for calcium uptake into the mitochondrial matrix. Here we present the cryo-electron microscopy structure of the full-length MCU from Neurospora crassa to an overall resolution of ~3.7 A. Our structure reveals a tetrameric architecture, with the soluble and transmembrane domains adopting different symmetric arrangements within the channel. The conserved W-D-Phi-Phi-E-P-V-T-Y sequence motif of MCU pore forms a selectivity filter comprising two acidic rings separated by one helical turn along the central axis of the channel pore. The structure combined with mutagenesis gives insight into the basis of calcium recognition.

 

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== References ==

[[Category: Chrysonilia crassa]]

[[Category: Herzik, M A.J]]

[[Category: Lander, G C]]

[[Category: Lee, S Y]]

[[Category: Wu, M]]

[[Category: Yin, Y]]

[[Category: Yoo, J]]

[[Category: Uniporter]]