6duz

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Current revision (14:36, 13 March 2024) (edit) (undo)
 
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<SX load='6duz' size='340' side='right' viewer='molstar' caption='[[6duz]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<SX load='6duz' size='340' side='right' viewer='molstar' caption='[[6duz]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6duz]] is a 48 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DUZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6duz]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DUZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6duz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6duz OCA], [http://pdbe.org/6duz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6duz RCSB], [http://www.ebi.ac.uk/pdbsum/6duz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6duz ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6duz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6duz OCA], [https://pdbe.org/6duz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6duz RCSB], [https://www.ebi.ac.uk/pdbsum/6duz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6duz ProSAT]</span></td></tr>
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</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRGH_SALTY PRGH_SALTY]] Required for invasion of epithelial cells. [[http://www.uniprot.org/uniprot/PRGK_SALTY PRGK_SALTY]] Required for invasion of epithelial cells. Could be involved in protein secretion.
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[https://www.uniprot.org/uniprot/PRGH_SALTY PRGH_SALTY] Required for invasion of epithelial cells.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is the needle complex, a continuous channel formed by the highly oligomerized inner and outer membrane hollow rings and a polymerized helical needle filament which spans through and projects into the infected host cell. Here we present the near-atomic resolution structure of a needle complex from the prototypical Salmonella Typhimurium SPI-1 type III secretion system, with local masking protocols allowing for model building and refinement of the major membrane spanning components of the needle complex base in addition to an isolated needle filament. This work provides significant insight into injectisome structure and assembly and importantly captures the molecular basis for substrate induced gating in the giant outer membrane secretin portal family.
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Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin.,Hu J, Worrall LJ, Hong C, Vuckovic M, Atkinson CE, Caveney N, Yu Z, Strynadka NCJ Nat Commun. 2018 Sep 21;9(1):3840. doi: 10.1038/s41467-018-06298-8. PMID:30242280<ref>PMID:30242280</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6duz" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Atkinson, C E]]
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[[Category: Atkinson CE]]
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[[Category: Hu, J]]
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[[Category: Hu J]]
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[[Category: Strynadka, N C.J]]
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[[Category: Strynadka NCJ]]
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[[Category: Vuckovic, M]]
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[[Category: Vuckovic M]]
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[[Category: Worrall, L J]]
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[[Category: Worrall LJ]]
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[[Category: Membrane protein]]
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[[Category: Type iii secretion system]]
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Current revision

Structure of the periplasmic domains of PrgH and PrgK from the assembled Salmonella type III secretion injectisome needle complex

6duz, resolution 3.60Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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